I’m unsure whether you mean something different by that as compared with what I meant by 4 orientations. I think you do … in which case if it makes a difference (I don’t know whether it does), yes, that could make it even worse (and more time consuming).
I think that in order to answer your question (“does it make a difference?”) would require a detailed knowledge of the USB-C spec and then a detailed knowledge of what faulty implementations are out there. Beyond my pay grade.
If you don’t need the full functionality of USB-C, there’s a lot to be said for USB-A-to-USB-C since then the ends can’t be swapped and the USB-A end only has one orientation. So just two orientations (and they are at the USB-C end). Obviously this only applies to a USB-A peripheral and equally obviously this does not apply to the Nexdock (as per the OP), which requires full USB-C functionality.