The only show stopping issue I had with Qubes is the graphics performance is awful. When you want to just relax and stream a video or something you have to deal with tons of tearing and the like. It is stuck on xorg with no compositer and no hardware acceleration, which just makes the overall visual experience pretty lackluster compared to any other system and the CPU has to work very hard to do simple graphic tasks, which in turn kicks up the fans from the heat generated. I’m hoping the GUI domain they have been working on helps out with these issues and then I would happily go back.