In the Librem 14 using the the Hardware Kill Switch for the wifi/bt results in the whole device to disappear from the PCIe bus.
To quote one of our team members:
Because it disappears from the PCIe bus entirely, Qubes reports that error, because it has assigned that PCIe device to the sys-net Xen VM
and it looks like Qubes isn’t handling the situation where a PCIe device disappears, gracefully, compared to, say, USB devices disappearing