@solr1, you ran the smartcard-key-luks script on QubesOS?
The script looks like it is expecting a Debian based system but dom0 is based on Fedora. With the sys-usb VM enabled on my Qubes system, my dom0 does not see the Librem Key to be able to generate the secret key.
If you are indeed using Qubes, how did you get the script or Librem Key to unlock your luks root drive?