I was looking through the gsettings and saw this gsettings set org.gnome.desktop.lockdown disable-lock-screen false I am just curious if this is safe to change or if I should just leave well enough alone.
Well, the “antidote” if something goes wrong would be to change true back to false, so you can probably risk it. 
Yeah it does nothing.
I cannot figure out how to change this setting to vertical instead of horizontal gsettings set org.gnome.desktop.interface toolbar-style 'both-horiz'
You might try pasting the command into your internet search engine to find references about its available options.
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No need for search engine in order to find out what the available options are.
gsettings describe org.gnome.desktop.interface toolbar-style
Toolbar Style. Valid values are “both”, “both-horiz”, “icons”, and “text”.
You might need a search engine (or the sources) to work out what they do. 
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