Mini v1 works with Qubes 4.0.3 stable
Mini v2 works with Qubes 4.1.0-alpha1 (and newer)
The dom0 kernel for 4.0.3 stable is too old to support the hardware in the Mini v2 (and upcoming Librem 14)
edit: Mini v2 (and Librem 14) will also work with 4.0.4 (stable)