From the doc: https://docs.puri.sm/PureBoot/Heads/User_Manual.html#heads-beta-installation-instructions
A Librem Laptop with a TPM chip running PureOS (sorry Qubes users, the dom0 flashrom is too old)
Just want to report that I just did it and it is working fine, no issue on the current version of Qubes OS to flash it from dom0
Build the rom / tools / and everything needed in a AppVM, then copy the result to dom0, then flash
( but needed to modify a bit the coreboot_util.sh script )