Are these images created reproducibly? I only know about the jenkins instance for Librem 5 images at https://arm01.puri.sm/ but maybe there is something similar for amd64 PureOS?
It seems this problem is not unusual and not specific to PureOS. In this discussion here someone mentions that genisoimage (which afaik is used to pack up files into a bootable iso file) wants to modify the isolinux.bin file, but this is done after the md5sum list is created.