Indeed when working all day long with a keyboard as the main tool you memorize it, even in the layers behind modifikation keys. Some people already stated they use a modern layout like Dvorak, Colemark or Neo. Which one highly depends on language used and what kind of stuff typed.
Some may have recognized that there are muck better keybindings for writing texts on Linux than on Windows when it comes to special characters and you can easily switch between languages as long as you have enough physical keys to map it. It’s just software.
Perfect would be customizeable key caps that can be labeled (e.g. with a laser or special printer), this way everybody could have keys to his needs. If some consider to have an (rather pricy) external keyboard to easy their work, WASD is a good option. A cheaper blank/black option ist das keyboard ultimate.
Unfortunately we do not have the numbers here for customizing, but skipping the white labels should not be much of a hassle?